BAIT
BICD1
B830009D06Rik, RP23-403F3.1
bicaudal D homolog 1 (Drosophila)
GO Process (9)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- microtubule anchoring at microtubule organizing center [IMP]
- minus-end-directed organelle transport along microtubule [ISO]
- negative regulation of phospholipase C activity [IDA]
- negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway [IDA, ISO]
- positive regulation of receptor-mediated endocytosis [ISO]
- protein localization to organelle [ISO]
- regulation of proteinase activated receptor activity [IDA]
- stress granule assembly [IMP]
- viral process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BCAR1
AI385681, Cas, Crkas
breast cancer anti-estrogen resistance 1
GO Process (17)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- G-protein coupled receptor signaling pathway [IDA]
- actin cytoskeleton organization [ISO]
- actin filament organization [ISO]
- antigen receptor-mediated signaling pathway [ISO]
- cell chemotaxis [ISO]
- cell migration [IDA, ISO]
- cellular response to hepatocyte growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- hepatocyte growth factor receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- integrin-mediated signaling pathway [ISO]
- neurotrophin TRK receptor signaling pathway [ISO]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of cell migration [ISO]
- positive regulation of endothelial cell migration [ISO]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
Signalling by target-derived neurotrophins is essential for the correct development of the nervous system and its maintenance throughout life. Several aspects concerning the lifecycle of neurotrophins and their receptors have been characterised over the years, including the formation, endocytosis and trafficking of signalling-competent ligand-receptor complexes. However, the molecular mechanisms directing the sorting of activated neurotrophin receptors are still elusive. Previously, ... [more]
J Cell Sci Dec. 30, 2019; 133(6); [Pubmed: 32079660]
Throughput
- High Throughput
Curated By
- BioGRID