BAIT
BICD1
B830009D06Rik, RP23-403F3.1
bicaudal D homolog 1 (Drosophila)
GO Process (9)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- microtubule anchoring at microtubule organizing center [IMP]
- minus-end-directed organelle transport along microtubule [ISO]
- negative regulation of phospholipase C activity [IDA]
- negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway [IDA, ISO]
- positive regulation of receptor-mediated endocytosis [ISO]
- protein localization to organelle [ISO]
- regulation of proteinase activated receptor activity [IDA]
- stress granule assembly [IMP]
- viral process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
C3
AI255234, ASP, HSE-MSF, Plp
complement component 3
GO Process (15)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- blood coagulation [ISO]
- complement activation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of G-protein coupled receptor protein signaling pathway [ISO]
- positive regulation of activation of membrane attack complex [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of apoptotic cell clearance [ISO]
- positive regulation of developmental growth [ISO]
- positive regulation of glucose transport [ISO]
- positive regulation of lipid storage [ISO]
- positive regulation of phagocytosis [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of type IIa hypersensitivity [IMP]
- positive regulation vascular endothelial growth factor production [ISO]
- regulation of triglyceride biosynthetic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
Signalling by target-derived neurotrophins is essential for the correct development of the nervous system and its maintenance throughout life. Several aspects concerning the lifecycle of neurotrophins and their receptors have been characterised over the years, including the formation, endocytosis and trafficking of signalling-competent ligand-receptor complexes. However, the molecular mechanisms directing the sorting of activated neurotrophin receptors are still elusive. Previously, ... [more]
J Cell Sci Dec. 30, 2019; 133(6); [Pubmed: 32079660]
Throughput
- High Throughput
Curated By
- BioGRID