BAIT
BICD1
B830009D06Rik, RP23-403F3.1
bicaudal D homolog 1 (Drosophila)
GO Process (9)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- microtubule anchoring at microtubule organizing center [IMP]
- minus-end-directed organelle transport along microtubule [ISO]
- negative regulation of phospholipase C activity [IDA]
- negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway [IDA, ISO]
- positive regulation of receptor-mediated endocytosis [ISO]
- protein localization to organelle [ISO]
- regulation of proteinase activated receptor activity [IDA]
- stress granule assembly [IMP]
- viral process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ARHGEF2
AA408978, GEF, GEF-H1, GEFH1, LFP40, Lbcl1, Lfc, P40, mKIAA0651
rho/rac guanine nucleotide exchange factor (GEF) 2
GO Process (14)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- actin filament organization [IPI, ISO]
- cell morphogenesis [IDA, ISO]
- cellular response to muramyl dipeptide [ISO]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of microtubule depolymerization [ISO]
- negative regulation of neurogenesis [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Rho GTPase activity [IDA, ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- regulation of Rho protein signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
Signalling by target-derived neurotrophins is essential for the correct development of the nervous system and its maintenance throughout life. Several aspects concerning the lifecycle of neurotrophins and their receptors have been characterised over the years, including the formation, endocytosis and trafficking of signalling-competent ligand-receptor complexes. However, the molecular mechanisms directing the sorting of activated neurotrophin receptors are still elusive. Previously, ... [more]
J Cell Sci Dec. 30, 2019; 133(6); [Pubmed: 32079660]
Throughput
- High Throughput
Curated By
- BioGRID