BICD1
Gene Ontology Biological Process
- microtubule anchoring at microtubule organizing center [IMP]
- minus-end-directed organelle transport along microtubule [ISO]
- negative regulation of phospholipase C activity [IDA]
- negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway [IDA, ISO]
- positive regulation of receptor-mediated endocytosis [ISO]
- protein localization to organelle [ISO]
- regulation of proteinase activated receptor activity [IDA]
- stress granule assembly [IMP]
- viral process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTPN23
Gene Ontology Biological Process
- cilium morphogenesis [ISO]
- negative regulation of epithelial cell migration [ISO]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of adherens junction organization [ISO]
- positive regulation of early endosome to late endosome transport [ISO]
- positive regulation of homophilic cell adhesion [ISO]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
Signalling by target-derived neurotrophins is essential for the correct development of the nervous system and its maintenance throughout life. Several aspects concerning the lifecycle of neurotrophins and their receptors have been characterised over the years, including the formation, endocytosis and trafficking of signalling-competent ligand-receptor complexes. However, the molecular mechanisms directing the sorting of activated neurotrophin receptors are still elusive. Previously, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BICD1 PTPN23 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID