BAIT
AATF
BFR2, CHE-1, CHE1, DED, HSPC277
apoptosis antagonizing transcription factor
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- cellular response to DNA damage stimulus [IEP]
- negative regulation of apoptotic process [IMP]
- negative regulation of reactive oxygen species metabolic process [IDA]
- negative regulation of superoxide anion generation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NCBP2
CBC2, CBP20, NIP1, PIG55
nuclear cap binding protein subunit 2, 20kDa
GO Process (21)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [IDA, TAS]
- RNA metabolic process [TAS]
- RNA splicing [ISS, TAS]
- gene expression [TAS]
- histone mRNA metabolic process [TAS]
- mRNA 3'-end processing [TAS]
- mRNA cis splicing, via spliceosome [IDA]
- mRNA export from nucleus [TAS]
- mRNA metabolic process [TAS]
- mRNA splicing, via spliceosome [TAS]
- ncRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IDA, IMP, TAS]
- positive regulation of RNA export from nucleus [ISS]
- positive regulation of viral transcription [TAS]
- regulation of translational initiation [IDA]
- snRNA export from nucleus [ISS, NAS]
- spliceosomal snRNP assembly [TAS]
- termination of RNA polymerase II transcription [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase II promoter [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.
AATF is a central regulator of the cellular outcome upon p53 activation, a finding that has primarily been attributed to its function as a transcription factor. Recent data showed that AATF is essential for ribosome biogenesis and plays a role in rRNA maturation. AATF has been implicated to fulfil this role through direct interaction with rRNA and was identified in ... [more]
Sci Rep Dec. 30, 2018; 9(1);11071 [Pubmed: 31363146]
Throughput
- High Throughput
Curated By
- BioGRID