BAIT
LOXL2
LOR2, WS9-14
lysyl oxidase-like 2
GO Process (15)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- aging [TAS]
- cell adhesion [TAS]
- cellular protein modification process [IDA]
- collagen fibril organization [IMP]
- endothelial cell migration [IMP]
- endothelial cell proliferation [IMP]
- epithelial to mesenchymal transition [IDA]
- histone modification [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- oxidation-reduction process [IDA]
- positive regulation of chondrocyte differentiation [ISS]
- protein deamination [IDA]
- response to copper ion [IDA]
- response to hypoxia [ISS]
- sprouting angiogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TFRC
CD71, T9, TFR, TFR1, TR, TRFR, p90
transferrin receptor
GO Process (6)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cell surface [IDA]
- coated pit [IDA]
- cytoplasmic membrane-bounded vesicle [IDA]
- endosome [IDA]
- extracellular region [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane [NAS]
- plasma membrane [TAS]
- recycling endosome [IDA]
- vesicle [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
LOXL2 Upregulates Phosphorylation of Ezrin to Promote Cytoskeletal Reorganization and Tumor Cell Invasion.
Lysyl oxidase-like 2 (LOXL2), a copper-dependent enzyme of the lysyl oxidase family and its nonsecreted, catalytically dead spliced isoform L2?13, enhance cell migration and invasion, stimulate filopodia formation, modulate the expression of cytoskeletal genes, and promote tumor development and metastasis in vivo. We previously showed that LOXL2 reorganizes the actin cytoskeleton in esophageal squamous cell carcinoma (ESCC) cells, however, the ... [more]
Cancer Res Oct. 01, 2019; 79(19);4951-4964 [Pubmed: 31409639]
Throughput
- High Throughput
Curated By
- BioGRID