BAIT
CYFIP2
1500004I01Rik, 6430511D02Rik, AA930218, AU022376, Pir121, mKIAA1168, RP23-370F7.1
cytoplasmic FMR1 interacting protein 2
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CHD5
4930532L22Rik, AW060752, B230399N07Rik, CHD-5, RP23-421E12.10-001
chromodomain helicase DNA binding protein 5
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cerebral cortex neuron differentiation [IMP]
- histone H3-K27 trimethylation [ISO]
- histone H4 acetylation [IMP]
- negative regulation of cell proliferation [IMP]
- positive regulation of signal transduction by p53 class mediator [IMP]
- regulation of cell differentiation [IMP]
- regulation of transcription involved in cell fate commitment [IMP, ISO]
- spermatogenesis, exchange of chromosomal proteins [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.
Variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene are associated with early-onset epileptic encephalopathy, intellectual disability, and developmental delay. However, the current understanding of the molecular functions of CYFIP2 is limited to those related to actin dynamics, and thus, the detailed mechanisms of CYFIP2-associated brain disorders remain largely unknown. Here, we isolated the neonatal forebrain CYFIP2 complex using newly ... [more]
Biochem Biophys Res Commun Dec. 13, 2019; 529(1);1-6 [Pubmed: 32560809]
Throughput
- High Throughput
Curated By
- BioGRID