BAIT
CYFIP2
1500004I01Rik, 6430511D02Rik, AA930218, AU022376, Pir121, mKIAA1168, RP23-370F7.1
cytoplasmic FMR1 interacting protein 2
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRNP
AA960666, AI325101, CD230, PrP, PrP, PrPC, PrPSc, Prn-i, Prn-p, Sinc, prP27-30, prP33-35C, RP23-401J24.1
prion protein
GO Process (19)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- cellular copper ion homeostasis [TAS]
- cellular response to copper ion [ISO]
- cellular response to drug [IDA]
- learning or memory [ISO]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of apoptotic process [IGI, ISO]
- negative regulation of calcineurin-NFAT signaling cascade [IMP]
- negative regulation of interferon-gamma production [IMP]
- negative regulation of interleukin-17 production [IMP]
- negative regulation of interleukin-2 production [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- nucleobase-containing compound metabolic process [TAS]
- regulation of potassium ion transmembrane transport [IGI]
- regulation of protein localization [IMP]
- response to cadmium ion [ISO]
- response to copper ion [ISO]
- response to oxidative stress [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.
Variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene are associated with early-onset epileptic encephalopathy, intellectual disability, and developmental delay. However, the current understanding of the molecular functions of CYFIP2 is limited to those related to actin dynamics, and thus, the detailed mechanisms of CYFIP2-associated brain disorders remain largely unknown. Here, we isolated the neonatal forebrain CYFIP2 complex using newly ... [more]
Biochem Biophys Res Commun Dec. 13, 2019; 529(1);1-6 [Pubmed: 32560809]
Throughput
- High Throughput
Curated By
- BioGRID