BAIT
CYFIP2
1500004I01Rik, 6430511D02Rik, AA930218, AU022376, Pir121, mKIAA1168, RP23-370F7.1
cytoplasmic FMR1 interacting protein 2
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DAG1
D9Wsu13e, DG, Dp427, Dp71
dystroglycan 1
GO Process (17)
GO Function (9)
GO Component (22)
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [ISO]
- Schwann cell development [IMP]
- basement membrane organization [IMP]
- branching involved in salivary gland morphogenesis [IMP]
- calcium-dependent cell-matrix adhesion [ISO]
- commissural neuron axon guidance [IMP]
- cytoskeletal anchoring at plasma membrane [ISO]
- epithelial tube branching involved in lung morphogenesis [IMP]
- membrane protein ectodomain proteolysis [ISO]
- microtubule anchoring [ISO]
- modulation by virus of host morphology or physiology [ISO]
- morphogenesis of an epithelial sheet [IMP]
- myelination in peripheral nervous system [IMP]
- negative regulation of MAPK cascade [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of protein kinase B signaling [ISO]
- nerve maturation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basement membrane [IDA, ISO]
- basolateral plasma membrane [ISO]
- cell outer membrane [IDA]
- cell-cell adherens junction [ISO]
- cell-cell junction [IDA]
- contractile ring [ISO]
- costamere [ISO]
- cytoplasm [ISO]
- dystroglycan complex [IDA]
- dystrophin-associated glycoprotein complex [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [ISO]
- integral component of membrane [ISO]
- lamellipodium [ISO]
- membrane [IDA]
- membrane raft [IDA]
- node of Ranvier [IMP]
- nucleoplasm [ISO]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.
Variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene are associated with early-onset epileptic encephalopathy, intellectual disability, and developmental delay. However, the current understanding of the molecular functions of CYFIP2 is limited to those related to actin dynamics, and thus, the detailed mechanisms of CYFIP2-associated brain disorders remain largely unknown. Here, we isolated the neonatal forebrain CYFIP2 complex using newly ... [more]
Biochem Biophys Res Commun Dec. 13, 2019; 529(1);1-6 [Pubmed: 32560809]
Throughput
- High Throughput
Curated By
- BioGRID