BAIT
CYFIP2
1500004I01Rik, 6430511D02Rik, AA930218, AU022376, Pir121, mKIAA1168, RP23-370F7.1
cytoplasmic FMR1 interacting protein 2
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SORBS1
2310065E01Rik, 9530001P15Rik, CAP, SH3P12, Sh3d5, mKIAA1296
sorbin and SH3 domain containing 1
GO Process (10)
GO Function (5)
GO Component (16)
Gene Ontology Biological Process
- cellular response to insulin stimulus [IC, IMP]
- focal adhesion assembly [IDA]
- glucose transport [IDA]
- insulin receptor signaling pathway [IC, IDA]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of glycogen biosynthetic process [IMP]
- positive regulation of lipid biosynthetic process [IMP]
- positive regulation of signal transduction [IPI]
- stress fiber assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell-cell adherens junction [IDA]
- cell-substrate adherens junction [IDA]
- centrosome [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- cytosol [IDA]
- flotillin complex [IC]
- focal adhesion [ISO]
- insulin receptor complex [ISO]
- membrane [IDA]
- membrane raft [IDA]
- nuclear matrix [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- stress fiber [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.
Variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene are associated with early-onset epileptic encephalopathy, intellectual disability, and developmental delay. However, the current understanding of the molecular functions of CYFIP2 is limited to those related to actin dynamics, and thus, the detailed mechanisms of CYFIP2-associated brain disorders remain largely unknown. Here, we isolated the neonatal forebrain CYFIP2 complex using newly ... [more]
Biochem Biophys Res Commun Dec. 13, 2019; 529(1);1-6 [Pubmed: 32560809]
Throughput
- High Throughput
Curated By
- BioGRID