BAIT
CYFIP2
1500004I01Rik, 6430511D02Rik, AA930218, AU022376, Pir121, mKIAA1168, RP23-370F7.1
cytoplasmic FMR1 interacting protein 2
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NIPBL
Idn3
Nipped-B homolog (Drosophila)
GO Process (34)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- brain development [ISO]
- cellular protein localization [ISO]
- cellular response to DNA damage stimulus [ISO]
- cellular response to X-ray [ISO]
- cognition [ISO]
- developmental growth [ISO]
- ear morphogenesis [ISO]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic digestive tract morphogenesis [ISO]
- embryonic forelimb morphogenesis [ISO]
- embryonic viscerocranium morphogenesis [IMP]
- external genitalia morphogenesis [ISO]
- eye morphogenesis [ISO]
- face morphogenesis [ISO]
- fat cell differentiation [IMP]
- forelimb morphogenesis [ISO]
- gall bladder development [ISO]
- heart development [IMP]
- heart morphogenesis [ISO]
- maintenance of mitotic sister chromatid cohesion [ISO]
- mitotic sister chromatid cohesion [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- outflow tract morphogenesis [ISO]
- positive regulation of histone deacetylation [ISO]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of ossification [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of developmental growth [ISO]
- regulation of embryonic development [ISO]
- regulation of hair cycle [ISO]
- sensory perception of sound [ISO]
- stem cell maintenance [IMP]
- uterus morphogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.
Variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene are associated with early-onset epileptic encephalopathy, intellectual disability, and developmental delay. However, the current understanding of the molecular functions of CYFIP2 is limited to those related to actin dynamics, and thus, the detailed mechanisms of CYFIP2-associated brain disorders remain largely unknown. Here, we isolated the neonatal forebrain CYFIP2 complex using newly ... [more]
Biochem Biophys Res Commun Dec. 13, 2019; 529(1);1-6 [Pubmed: 32560809]
Throughput
- High Throughput
Curated By
- BioGRID