BAIT
CYFIP2
1500004I01Rik, 6430511D02Rik, AA930218, AU022376, Pir121, mKIAA1168, RP23-370F7.1
cytoplasmic FMR1 interacting protein 2
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WHSC1
5830445G22Rik, 9430010A17Rik, AW555663, C130020C13Rik, D030027O06Rik, D930023B08Rik, MMSET, NSD2, Whsc1l, mKIAA1090
Wolf-Hirschhorn syndrome candidate 1 (human)
GO Process (13)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- atrial septum primum morphogenesis [IMP]
- atrial septum secundum morphogenesis [IMP]
- bone development [IMP]
- chromatin modification [IDA]
- histone H3-K36 methylation [IDA]
- histone H4-K20 methylation [IDA]
- membranous septum morphogenesis [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- peptidyl-lysine methylation [IDA]
- positive regulation of isotype switching to IgA isotypes [IMP]
- regulation of double-strand break repair via nonhomologous end joining [IMP]
- regulation of establishment of protein localization [IMP]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.
Variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene are associated with early-onset epileptic encephalopathy, intellectual disability, and developmental delay. However, the current understanding of the molecular functions of CYFIP2 is limited to those related to actin dynamics, and thus, the detailed mechanisms of CYFIP2-associated brain disorders remain largely unknown. Here, we isolated the neonatal forebrain CYFIP2 complex using newly ... [more]
Biochem Biophys Res Commun Dec. 13, 2019; 529(1);1-6 [Pubmed: 32560809]
Throughput
- High Throughput
Curated By
- BioGRID