BAIT
CYFIP2
1500004I01Rik, 6430511D02Rik, AA930218, AU022376, Pir121, mKIAA1168, RP23-370F7.1
cytoplasmic FMR1 interacting protein 2
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SEMA7A
2900057C09Rik, CDw108, H-Sema-L, M-Sema-L, Semal
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
GO Process (10)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- axon extension [IDA, IGI, IMP]
- integrin-mediated signaling pathway [IDA, ISO]
- neuron projection development [IMP]
- olfactory lobe development [IDA, IMP]
- osteoblast differentiation [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISO]
- positive regulation of axon extension [IDA, ISO]
- positive regulation of macrophage cytokine production [IDA]
- positive regulation of protein phosphorylation [IDA]
- regulation of inflammatory response [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.
Variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene are associated with early-onset epileptic encephalopathy, intellectual disability, and developmental delay. However, the current understanding of the molecular functions of CYFIP2 is limited to those related to actin dynamics, and thus, the detailed mechanisms of CYFIP2-associated brain disorders remain largely unknown. Here, we isolated the neonatal forebrain CYFIP2 complex using newly ... [more]
Biochem Biophys Res Commun Dec. 13, 2019; 529(1);1-6 [Pubmed: 32560809]
Throughput
- High Throughput
Curated By
- BioGRID