BAIT

AGO2

EIF2C2, Q10

argonaute RISC catalytic component 2

GO Process (18)

GO Function (7)

GO Component (9)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

Notch signaling pathway [TAS]

RNA phosphodiester bond hydrolysis, endonucleolytic [EXP, IDA]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

gene expression [TAS]

gene silencing by RNA [ISS]

innate immune response [TAS]

mRNA cleavage involved in gene silencing by miRNA [IDA, IMP]

negative regulation of translation involved in gene silencing by miRNA [IDA, IMP]

negative regulation of translational initiation [IDA]

neurotrophin TRK receptor signaling pathway [TAS]

phosphatidylinositol-mediated signaling [TAS]

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]

pre-miRNA processing [IDA]

translation [NAS]

translational initiation [NAS]

Gene Ontology Molecular Function

RNA 7-methylguanosine cap binding [IDA]
endoribonuclease activity [EXP]
endoribonuclease activity, cleaving siRNA-paired mRNA [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]
siRNA binding [IDA]
translation initiation factor activity [NAS]

Gene Ontology Cellular Component

RISC complex [IDA]

cytoplasm [IDA]

cytoplasmic mRNA processing body [IDA]

mRNA cap binding complex [IDA]

micro-ribonucleoprotein complex [IDA]

ribonucleoprotein complex [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

CYFIP2

PIR121

cytoplasmic FMR1 interacting protein 2

Alzheimer's Disease Project

GO Process (6)

GO Function (1)

GO Component (6)

Gene Ontology Biological Process

Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]

activation of cysteine-type endopeptidase activity [IDA]

apoptotic process [IDA]

innate immune response [TAS]

positive regulation of proteolysis [IDA]

single organismal cell-cell adhesion [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

perinuclear region of cytoplasm [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.

Lee Y, Zhang Y, Kang H, Bang G, Kim Y, Kang HR, Ma R, Jin C, Kim JY, Han K

Variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene are associated with early-onset epileptic encephalopathy, intellectual disability, and developmental delay. However, the current understanding of the molecular functions of CYFIP2 is limited to those related to actin dynamics, and thus, the detailed mechanisms of CYFIP2-associated brain disorders remain largely unknown. Here, we isolated the neonatal forebrain CYFIP2 complex using newly ... [more]

Biochem Biophys Res Commun Dec. 13, 2019; 529(1);1-6 [Pubmed: 32560809]

Throughput

Low Throughput

Curated By

BioGRID