BAIT
RNF113A
Cwc24, RNF113, ZNF183
ring finger protein 113A
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
DICER1
DCR1, Dicer, Dicer1e, HERNA, K12H4.8-LIKE, MNG1, RMSE2
dicer 1, ribonuclease type III
GO Process (15)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, IMP]
- conversion of ds siRNA to ss siRNA [IMP]
- gene expression [TAS]
- negative regulation of Schwann cell proliferation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- nerve development [ISS]
- neuron projection morphogenesis [ISS]
- peripheral nervous system myelin formation [ISS]
- positive regulation of Schwann cell differentiation [ISS]
- positive regulation of myelination [ISS]
- pre-miRNA processing [IDA]
- production of miRNAs involved in gene silencing by miRNA [ISS]
- production of siRNA involved in RNA interference [IDA]
- targeting of mRNA for destruction involved in RNA interference [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.
Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivity to alkylation-based chemotherapy. RNF113A methylation by SMYD3 impairs its interaction with the phosphatase PP4, controlling its phosphorylation levels. This cross-talk between posttranslational modifications ... [more]
Cancer Discov Dec. 02, 2021; 12(9);2158-2179 [Pubmed: 35819319]
Throughput
- Low Throughput
Curated By
- BioGRID