BAIT
DDX39B
BAT1, D6S81E, UAP56, DAAP-97M17.4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
GO Process (9)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [IDA, TAS]
- RNA secondary structure unwinding [IDA]
- RNA splicing [IDA]
- mRNA export from nucleus [IDA, IGI]
- mRNA splicing, via spliceosome [IGI]
- negative regulation of DNA damage checkpoint [IMP]
- positive regulation of DNA-templated transcription, elongation [IMP]
- spliceosomal complex assembly [IDA]
- viral mRNA export from host cell nucleus [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
IMMT
HMP, MINOS2, P87, P87/89, P89, PIG52, PIG4
inner membrane protein, mitochondrial
GO Process (0)
GO Function (2)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2.
Metastasis is a major cause of colorectal cancer (CRC) mortality, but its molecular mechanisms are still not fully understood. Here, we show that upregulated DDX39B correlates with liver metastases and aggressive phenotypes in CRC. DDX39B is an independent prognostic factor associated with poor clinical outcome in CRC patients. We demonstrate that Sp1 potently activates DDX39B transcription by directly binding to ... [more]
Signal Transduct Target Ther Dec. 17, 2021; 7(1);275 [Pubmed: 35973989]
Throughput
- High Throughput
Curated By
- BioGRID