BAIT
GATA4
ASD2, TACHD, TOF, VSD1
GATA binding protein 4
GO Process (23)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- atrial septum morphogenesis [IMP]
- atrial septum primum morphogenesis [ISS]
- atrial septum secundum morphogenesis [IMP]
- blood coagulation [TAS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac ventricle morphogenesis [TAS]
- cell-cell signaling [ISS]
- embryonic foregut morphogenesis [ISS]
- embryonic heart tube anterior/posterior pattern specification [ISS]
- endocardial cushion development [IMP, ISS]
- endoderm development [TAS]
- heart looping [ISS]
- intestinal epithelial cell differentiation [IDA]
- male gonad development [IEP, IMP]
- positive regulation of angiogenesis [ISS]
- positive regulation of cardioblast differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- regulation of transcription, DNA-templated [ISS]
- response to drug [IMP]
- transcription from RNA polymerase II promoter [ISS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function- DNA binding [IDA, ISS]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- activating transcription factor binding [ISS]
- co-SMAD binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, ISS]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- activating transcription factor binding [ISS]
- co-SMAD binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPB1
CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27
heat shock 27kDa protein 1
GO Process (21)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular component movement [TAS]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- gene expression [TAS]
- intracellular signal transduction [IMP]
- mRNA metabolic process [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISS]
- negative regulation of protein kinase activity [ISS]
- platelet aggregation [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood vessel endothelial cell migration [IMP]
- positive regulation of endothelial cell chemotaxis [IMP]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IMP]
- positive regulation of interleukin-1 beta production [ISS]
- positive regulation of tumor necrosis factor biosynthetic process [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- regulation of translational initiation [TAS]
- response to unfolded protein [NAS]
- response to virus [IEP]
- retina homeostasis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcription factor protein interactomes reveal genetic determinants in heart disease.
Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein interactomes of transcription factors whose mutations cause CHDs. Defining the interactomes of two transcription factors haplo-insufficient in CHD, GATA4 and TBX5, within human cardiac progenitors, and integrating the results with ... [more]
Cell Dec. 03, 2021; 185(5);794-814.e30 [Pubmed: 35182466]
Throughput
- High Throughput
Additional Notes
- Experiment carried out in human induced pluripotent stem-cell-derived cardiac progenitors cells (CPs)
Curated By
- BioGRID