BAIT
GATA4
ASD2, TACHD, TOF, VSD1
GATA binding protein 4
GO Process (23)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- atrial septum morphogenesis [IMP]
- atrial septum primum morphogenesis [ISS]
- atrial septum secundum morphogenesis [IMP]
- blood coagulation [TAS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac ventricle morphogenesis [TAS]
- cell-cell signaling [ISS]
- embryonic foregut morphogenesis [ISS]
- embryonic heart tube anterior/posterior pattern specification [ISS]
- endocardial cushion development [IMP, ISS]
- endoderm development [TAS]
- heart looping [ISS]
- intestinal epithelial cell differentiation [IDA]
- male gonad development [IEP, IMP]
- positive regulation of angiogenesis [ISS]
- positive regulation of cardioblast differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation vascular endothelial growth factor production [ISS]
- regulation of transcription, DNA-templated [ISS]
- response to drug [IMP]
- transcription from RNA polymerase II promoter [ISS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function- DNA binding [IDA, ISS]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- activating transcription factor binding [ISS]
- co-SMAD binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA, ISS]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- activating transcription factor binding [ISS]
- co-SMAD binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPD1
CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13
heat shock 60kDa protein 1 (chaperonin)
GO Process (24)
GO Function (11)
GO Component (16)
Gene Ontology Biological Process
- 'de novo' protein folding [ISS]
- ATP catabolic process [ISS]
- B cell activation [IDA]
- B cell cytokine production [IDA]
- B cell proliferation [IDA]
- MyD88-dependent toll-like receptor signaling pathway [IDA]
- T cell activation [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- chaperone-mediated protein complex assembly [ISS]
- isotype switching to IgG isotypes [IDA]
- negative regulation of apoptotic process [IMP]
- positive regulation of T cell activation [IDA, ISS]
- positive regulation of T cell mediated immune response to tumor cell [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of interferon-alpha production [IDA]
- positive regulation of interferon-gamma production [IDA, ISS]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of macrophage activation [IDA]
- protein maturation [ISS]
- protein refolding [IDA]
- protein stabilization [IMP, ISS]
- response to unfolded protein [IDA]
Gene Ontology Molecular Function- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
- ATPase activity [ISS]
- DNA replication origin binding [ISS]
- chaperone binding [IPI]
- double-stranded RNA binding [IDA]
- lipopolysaccharide binding [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- single-stranded DNA binding [ISS]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IC, ISS]
Gene Ontology Cellular Component
- cell surface [IDA]
- coated pit [IDA]
- coated vesicle [IDA]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- lipopolysaccharide receptor complex [IDA]
- membrane [IDA]
- mitochondrial inner membrane [ISS]
- mitochondrial matrix [TAS]
- mitochondrion [IDA]
- protein complex [IDA]
- secretory granule [ISS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcription factor protein interactomes reveal genetic determinants in heart disease.
Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein interactomes of transcription factors whose mutations cause CHDs. Defining the interactomes of two transcription factors haplo-insufficient in CHD, GATA4 and TBX5, within human cardiac progenitors, and integrating the results with ... [more]
Cell Dec. 03, 2021; 185(5);794-814.e30 [Pubmed: 35182466]
Throughput
- High Throughput
Additional Notes
- Experiment carried out in HEK293 cells
Curated By
- BioGRID