BAIT
TBX5
HOS
T-box 5
GO Process (20)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- apoptotic nuclear changes [IDA]
- cardiac left ventricle formation [ISS]
- cell migration involved in coronary vasculogenesis [TAS]
- cell-cell signaling [IDA]
- embryonic forelimb morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- forelimb morphogenesis [IMP]
- gene expression [TAS]
- heart development [IDA, IMP]
- negative regulation of cardiac muscle cell proliferation [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial to mesenchymal transition [TAS]
- pericardium development [IDA]
- positive regulation of cardioblast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of execution phase of apoptosis [IC]
- transcription initiation from RNA polymerase II promoter [TAS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PSMD11
Rpn6, S9, p44.5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
GO Process (24)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- RNA metabolic process [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- proteasome assembly [IMP]
- protein polyubiquitination [TAS]
- regulation of apoptotic process [TAS]
- regulation of cellular amino acid metabolic process [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- stem cell differentiation [IMP]
- ubiquitin-dependent protein catabolic process [IMP]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcription factor protein interactomes reveal genetic determinants in heart disease.
Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein interactomes of transcription factors whose mutations cause CHDs. Defining the interactomes of two transcription factors haplo-insufficient in CHD, GATA4 and TBX5, within human cardiac progenitors, and integrating the results with ... [more]
Cell Dec. 03, 2021; 185(5);794-814.e30 [Pubmed: 35182466]
Throughput
- High Throughput
Additional Notes
- Experiment carried out in HEK293 cells
Curated By
- BioGRID