BAIT
TBX5
HOS
T-box 5
GO Process (20)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- apoptotic nuclear changes [IDA]
- cardiac left ventricle formation [ISS]
- cell migration involved in coronary vasculogenesis [TAS]
- cell-cell signaling [IDA]
- embryonic forelimb morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- forelimb morphogenesis [IMP]
- gene expression [TAS]
- heart development [IDA, IMP]
- negative regulation of cardiac muscle cell proliferation [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial to mesenchymal transition [TAS]
- pericardium development [IDA]
- positive regulation of cardioblast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of execution phase of apoptosis [IC]
- transcription initiation from RNA polymerase II promoter [TAS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
VAPB
ALS8, VAMP-B, VAP-B, RP5-1018E9.1
VAMP (vesicle-associated membrane protein)-associated protein B and C
GO Process (16)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- COPII-coated vesicle budding [IMP]
- ER to Golgi vesicle-mediated transport [IMP]
- activation of signaling protein activity involved in unfolded protein response [IDA]
- cellular calcium ion homeostasis [IMP]
- endoplasmic reticulum organization [IMP]
- endoplasmic reticulum unfolded protein response [IMP]
- modulation by virus of host morphology or physiology [IDA]
- negative regulation by host of viral genome replication [IDA]
- negative regulation by host of viral release from host cell [IDA]
- negative regulation by virus of viral protein levels in host cell [IDA]
- positive regulation by host of viral genome replication [IDA]
- positive regulation by host of viral release from host cell [IDA]
- positive regulation of viral genome replication [IMP]
- small molecule metabolic process [TAS]
- sphingolipid biosynthetic process [TAS]
- sphingolipid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcription factor protein interactomes reveal genetic determinants in heart disease.
Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein interactomes of transcription factors whose mutations cause CHDs. Defining the interactomes of two transcription factors haplo-insufficient in CHD, GATA4 and TBX5, within human cardiac progenitors, and integrating the results with ... [more]
Cell Dec. 03, 2021; 185(5);794-814.e30 [Pubmed: 35182466]
Throughput
- High Throughput
Additional Notes
- Experiment carried out in HEK293 cells
Curated By
- BioGRID