TBX5
Gene Ontology Biological Process
- apoptotic nuclear changes [IDA]
- cardiac left ventricle formation [ISS]
- cell migration involved in coronary vasculogenesis [TAS]
- cell-cell signaling [IDA]
- embryonic forelimb morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- forelimb morphogenesis [IMP]
- gene expression [TAS]
- heart development [IDA, IMP]
- negative regulation of cardiac muscle cell proliferation [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial to mesenchymal transition [TAS]
- pericardium development [IDA]
- positive regulation of cardioblast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of execution phase of apoptosis [IC]
- transcription initiation from RNA polymerase II promoter [TAS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function
BAIAP2
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- actin crosslink formation [ISS]
- actin filament bundle assembly [ISS]
- axonogenesis [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cell shape [ISS]
- response to bacterium [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Transcription factor protein interactomes reveal genetic determinants in heart disease.
Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein interactomes of transcription factors whose mutations cause CHDs. Defining the interactomes of two transcription factors haplo-insufficient in CHD, GATA4 and TBX5, within human cardiac progenitors, and integrating the results with ... [more]
Throughput
- High Throughput
Additional Notes
- Experiment carried out in HEK293 cells
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TBX5 BAIAP2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2702656 |
Curated By
- BioGRID