An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

USP10 deubiquitinates Tau, mediating its aggregation.

Wei Z, Zeng K, Hu J, Li X, Huang F, Zhang B, Wang JZ, Liu R, Li HL, Wang X

Normal Tau promotes the assembly and stabilization of microtubules, thus, maintaining axon transport. In Alzheimer's disease (AD), Tau aggregation causes it to lose these above-mentioned functions. However, the molecular mechanism leading to Tau aggregation in AD remains ambiguous. Here, we report that USP10, one of the important deubiquitinases (DUBs), is involved in Tau aggregation. We found that USP10 is upregulated ... [more]

Cell Death Dis Aug. 20, 2022; 13(8);726 [Pubmed: 35987808]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

USP10

Gene Ontology Biological Process

Gene Ontology Molecular Function

cysteine-type endopeptidase activity [IMP]ion channel binding [IDA]p53 binding [IPI]poly(A) RNA binding [IDA]protein binding [IPI]ubiquitin thiolesterase activity [IDA, IMP]ubiquitin-specific protease activity [IDA, IMP]

Gene Ontology Cellular Component

AOX1