BAIT
USP10
UBPO
ubiquitin specific peptidase 10
GO Process (5)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
LAMA5
AA408760, AA408762, AI853660, [a]5, laminin-511, mKIAA0533, RP23-16P3.3
laminin, alpha 5
GO Process (17)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- branching involved in salivary gland morphogenesis [IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- branching morphogenesis of an epithelial tube [IMP]
- cell migration [ISO]
- cilium assembly [IMP]
- establishment of protein localization to plasma membrane [IMP]
- hair follicle development [IMP]
- integrin-mediated signaling pathway [ISO]
- lung development [IMP]
- morphogenesis of a polarized epithelium [IMP]
- morphogenesis of embryonic epithelium [IMP]
- muscle organ development [IMP]
- neural crest cell migration [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- organ morphogenesis [IMP]
- regulation of cell proliferation [IMP]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP10 deubiquitinates Tau, mediating its aggregation.
Normal Tau promotes the assembly and stabilization of microtubules, thus, maintaining axon transport. In Alzheimer's disease (AD), Tau aggregation causes it to lose these above-mentioned functions. However, the molecular mechanism leading to Tau aggregation in AD remains ambiguous. Here, we report that USP10, one of the important deubiquitinases (DUBs), is involved in Tau aggregation. We found that USP10 is upregulated ... [more]
Cell Death Dis Aug. 20, 2022; 13(8);726 [Pubmed: 35987808]
Throughput
- High Throughput
Curated By
- BioGRID