BAIT
USP10
UBPO
ubiquitin specific peptidase 10
GO Process (5)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CADM1
2900073G06Rik, 3100001I08Rik, AI987920, Bl2, Igsf4, Igsf4a, Necl2, RA175, RA175A, RA175B, RA175C, RA175N, ST17, SgIGSF, SynCam, Tslc1
cell adhesion molecule 1
GO Process (13)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- bone development [IMP]
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [IDA]
- cell adhesion [IDA]
- cell recognition [IDA, ISO]
- detection of stimulus [IDA, ISO]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- liver development [ISO]
- positive regulation of cytokine secretion [ISO]
- positive regulation of natural killer cell mediated cytotoxicity [IDA, ISO]
- susceptibility to natural killer cell mediated cytotoxicity [IDA, ISO]
- synapse assembly [IDA]
- unidimensional cell growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP10 deubiquitinates Tau, mediating its aggregation.
Normal Tau promotes the assembly and stabilization of microtubules, thus, maintaining axon transport. In Alzheimer's disease (AD), Tau aggregation causes it to lose these above-mentioned functions. However, the molecular mechanism leading to Tau aggregation in AD remains ambiguous. Here, we report that USP10, one of the important deubiquitinases (DUBs), is involved in Tau aggregation. We found that USP10 is upregulated ... [more]
Cell Death Dis Aug. 20, 2022; 13(8);726 [Pubmed: 35987808]
Throughput
- High Throughput
Curated By
- BioGRID