BAIT
MT3
GIF, GIFB, GRIF, ZnMT3
metallothionein 3
GO Process (48)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- activation of protein kinase B activity [IDA]
- astrocyte development [ISS]
- cadmium ion homeostasis [IDA]
- cell proliferation [TAS]
- cellular lipid catabolic process [ISS]
- cellular metal ion homeostasis [NAS, TAS]
- cellular response to cadmium ion [IDA]
- cellular response to drug [IDA]
- cellular response to hypoxia [IEP]
- cellular response to nitric oxide [IDA]
- cellular response to oxidative stress [IEP]
- cellular zinc ion homeostasis [ISS]
- cholesterol catabolic process [ISS]
- energy reserve metabolic process [ISS]
- histone modification [IMP]
- leptin-mediated signaling pathway [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of autophagy [ISS]
- negative regulation of axon extension [IDA]
- negative regulation of cell growth [IDA, IMP, TAS]
- negative regulation of cysteine-type endopeptidase activity [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of necrotic cell death [IDA, ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of oxidoreductase activity [IDA]
- negative regulation of reactive oxygen species metabolic process [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of catalytic activity [ISS]
- positive regulation of cell death [IDA, ISS]
- positive regulation of gene expression [IDA, ISS]
- positive regulation of lysosomal membrane permeability [ISS]
- positive regulation of necrotic cell death [IDA]
- positive regulation of oxygen metabolic process [ISS]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- protein import into nucleus, translocation [IDA]
- protein kinase B signaling [IDA]
- protein stabilization [IDA]
- regulation of protein glycosylation [ISS]
- regulation of response to food [ISS]
- removal of superoxide radicals [IDA]
- response to hypoxia [IDA]
- zinc ion homeostasis [IDA]
- zinc ion transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ALDOA
ALDA, GSD12, HEL-S-87p
aldolase A, fructose-bisphosphate
GO Process (16)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- ATP biosynthetic process [IMP]
- actin filament organization [TAS]
- blood coagulation [TAS]
- carbohydrate metabolic process [TAS]
- fructose 1,6-bisphosphate metabolic process [IDA]
- fructose metabolic process [IMP]
- gluconeogenesis [TAS]
- glucose metabolic process [TAS]
- glycolytic process [IMP, TAS]
- muscle cell cellular homeostasis [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- protein homotetramerization [ISS]
- regulation of cell shape [IDA]
- small molecule metabolic process [TAS]
- striated muscle contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells.
Metallothionein 3 (MT-3) is a small, cysteine-rich protein that binds to essential metals required for homeostasis, as well as to heavy metals that have the potential to exert toxic effects on cells. MT-3 is expressed by epithelial cells of the human kidney, including the cells of the proximal tubule. Our laboratory has previously shown that mortal cultures of human proximal ... [more]
PLoS One May. 04, 2022; 17(5);e0267599 [Pubmed: 35503771]
Throughput
- Low Throughput
Curated By
- BioGRID