MT3
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- activation of protein kinase B activity [IDA]
- astrocyte development [ISS]
- cadmium ion homeostasis [IDA]
- cell proliferation [TAS]
- cellular lipid catabolic process [ISS]
- cellular metal ion homeostasis [NAS, TAS]
- cellular response to cadmium ion [IDA]
- cellular response to drug [IDA]
- cellular response to hypoxia [IEP]
- cellular response to nitric oxide [IDA]
- cellular response to oxidative stress [IEP]
- cellular zinc ion homeostasis [ISS]
- cholesterol catabolic process [ISS]
- energy reserve metabolic process [ISS]
- histone modification [IMP]
- leptin-mediated signaling pathway [ISS]
- negative regulation of apoptotic process [IDA]
- negative regulation of autophagy [ISS]
- negative regulation of axon extension [IDA]
- negative regulation of cell growth [IDA, IMP, TAS]
- negative regulation of cysteine-type endopeptidase activity [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of necrotic cell death [IDA, ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of oxidoreductase activity [IDA]
- negative regulation of reactive oxygen species metabolic process [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISS]
- positive regulation of catalytic activity [ISS]
- positive regulation of cell death [IDA, ISS]
- positive regulation of gene expression [IDA, ISS]
- positive regulation of lysosomal membrane permeability [ISS]
- positive regulation of necrotic cell death [IDA]
- positive regulation of oxygen metabolic process [ISS]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- protein import into nucleus, translocation [IDA]
- protein kinase B signaling [IDA]
- protein stabilization [IDA]
- regulation of protein glycosylation [ISS]
- regulation of response to food [ISS]
- removal of superoxide radicals [IDA]
- response to hypoxia [IDA]
- zinc ion homeostasis [IDA]
- zinc ion transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ACTB
Gene Ontology Biological Process
- 'de novo' posttranslational protein folding [TAS]
- ATP-dependent chromatin remodeling [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- adherens junction organization [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component movement [TAS]
- cellular protein metabolic process [TAS]
- chromatin organization [TAS]
- innate immune response [TAS]
- membrane organization [TAS]
- platelet aggregation [IMP]
- protein folding [TAS]
- retina homeostasis [IEP]
- substantia nigra development [IEP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- Tat protein binding [IPI]
- kinesin binding [IPI]
- nitric-oxide synthase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- structural constituent of cytoskeleton [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- Tat protein binding [IPI]
- kinesin binding [IPI]
- nitric-oxide synthase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- structural constituent of cytoskeleton [TAS]
Gene Ontology Cellular Component
- MLL5-L complex [IDA]
- NuA4 histone acetyltransferase complex [IDA]
- blood microparticle [IDA]
- cytoplasm [TAS]
- cytoplasmic ribonucleoprotein granule [IDA]
- cytoskeleton [TAS]
- cytosol [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- membrane [IDA]
- nuclear chromatin [IDA]
- nucleoplasm [TAS]
- protein complex [IDA]
- ribonucleoprotein complex [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protein interactions with metallothionein-3 promote vectorial active transport in human proximal tubular cells.
Metallothionein 3 (MT-3) is a small, cysteine-rich protein that binds to essential metals required for homeostasis, as well as to heavy metals that have the potential to exert toxic effects on cells. MT-3 is expressed by epithelial cells of the human kidney, including the cells of the proximal tubule. Our laboratory has previously shown that mortal cultures of human proximal ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MT3 ACTB | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID