BAIT
CDC73
C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
cell division cycle 73
GO Process (17)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISS]
- endodermal cell fate commitment [ISS]
- histone H2B ubiquitination [IDA]
- histone monoubiquitination [IDA]
- mRNA polyadenylation [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of mRNA 3'-end processing [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein destabilization [IMP]
- stem cell maintenance [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FHL2
AAG11, DRAL, FHL-2, SLIM-3, SLIM3
four and a half LIM domains 2
GO Process (7)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- androgen receptor signaling pathway [NAS]
- cellular lipid metabolic process [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [NAS]
- response to hormone [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.
BACKGROUND: Germline and somatic inactivating mutations in the HRPT2 gene occur in the inherited hyperparathyroidism-jaw tumor syndrome, in some cases of parathyroid cancer and in some cases of familial hyperparathyroidism. HRPT2 encodes parafibromin. To identify parafibromin interacting proteins we used the yeast two-hybrid system for screening a heart cDNA library with parafibromin as the bait. RESULTS: Fourteen parafibromin interaction positive ... [more]
Mol. Cancer Aug. 09, 2008; 7(0);65 [Pubmed: 18687124]
Throughput
- Low Throughput
Curated By
- BioGRID