BAIT

SDH3

CYB3, YKL4, succinate dehydrogenase cytochrome b subunit SDH3, L000001825, YKL141W
Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog, SHH3, that arose from the whole genome duplication
Saccharomyces cerevisiae (S288c)
PREY

URA1

dihydroorotate dehydrogenase, L000002430, YKL216W
Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Multiple knockout analysis of genetic robustness in the yeast metabolic network.

Deutscher D, Meilijson I, Kupiec M, Ruppin E

Genetic robustness characterizes the constancy of the phenotype in face of heritable perturbations. Previous investigations have used comprehensive single and double gene knockouts to study gene essentiality and pairwise gene interactions in the yeast Saccharomyces cerevisiae. Here we conduct an in silico multiple knockout investigation of a flux balance analysis model of the yeast's metabolic network. Cataloging gene sets that ... [more]

Nat. Genet. Sep. 01, 2006; 38(9);993-8 [Pubmed: 16941010]

Throughput

  • High Throughput|Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • COX1/SDH3/URA1 triple mutant is synthetic lethal in synthetic rich media
  • RIP1/SDH3/URA1 mutants are synthetic lethal in minimal media
  • RIP1/SDH3/URA1 triple mutant is synthetic lethal in synthetic rich media
  • genetic complex

Curated By

  • BioGRID