BAIT

ARO7

HGS1, OSM2, TYR7, chorismate mutase ARO7, L000000120, YPR060C
Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

NQM1

sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1, YGR043C
Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Multiple knockout analysis of genetic robustness in the yeast metabolic network.

Deutscher D, Meilijson I, Kupiec M, Ruppin E

Genetic robustness characterizes the constancy of the phenotype in face of heritable perturbations. Previous investigations have used comprehensive single and double gene knockouts to study gene essentiality and pairwise gene interactions in the yeast Saccharomyces cerevisiae. Here we conduct an in silico multiple knockout investigation of a flux balance analysis model of the yeast's metabolic network. Cataloging gene sets that ... [more]

Nat. Genet. Sep. 01, 2006; 38(9);993-8 [Pubmed: 16941010]

Throughput

  • High Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • ARO7/TAL1/ZWF1/YGR043C quadruple mutant is synthetic lethal in synthetic rich media
  • genetic complex

Curated By

  • BioGRID