BAIT
CTA1
catalase A, L000000428, YDR256C
Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- catalase activity [IDA, IGI, IMP]
- catalase activity [IDA, IGI, IMP]
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
GLR1
LPG17, glutathione-disulfide reductase GLR1, L000000714, YPL091W
Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress
GO Process (4)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Multiple knockout analysis of genetic robustness in the yeast metabolic network.
Genetic robustness characterizes the constancy of the phenotype in face of heritable perturbations. Previous investigations have used comprehensive single and double gene knockouts to study gene essentiality and pairwise gene interactions in the yeast Saccharomyces cerevisiae. Here we conduct an in silico multiple knockout investigation of a flux balance analysis model of the yeast's metabolic network. Cataloging gene sets that ... [more]
Nat. Genet. Sep. 01, 2006; 38(9);993-8 [Pubmed: 16941010]
Throughput
- High Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- CTA1/CTT1/GLR1/PyrD quadruple mutant is synthetic lethal in synthetic rich media
- genetic complex
Curated By
- BioGRID