BAIT
SIAH1
SIAH1A
siah E3 ubiquitin protein ligase 1
GO Process (11)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- nervous system development [TAS]
- neuron apoptotic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- protein catabolic process [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISS]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
PIAS2
ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4
protein inhibitor of activated STAT, 2
GO Process (4)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.
Protein inhibitor of activated STAT (Pias) and human homologues of seven in absentia (hSiah) proteins both exhibit properties of ubiquitin-family peptides conjugating enzymes. Pias present E3-ligase activity for small ubiquitin-related modifiers (Sumo) covalent attachment to their targets. This post-translational modification is responsible for the activation of different transcription factors such as AP1. HSiah proteins possess ubiquitin-E3-ligase activity that triggers their ... [more]
Oncogene Oct. 11, 2007; 26(46);6665-76 [Pubmed: 17533377]
Throughput
- Low Throughput
Curated By
- BioGRID