BAIT

CHIC2

BTL
cysteine-rich hydrophobic domain 2
Glioblastoma Project
GO Process (1)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

IFITM2

DSPA2c, Ifitm3l, fragilis3, mil-3
interferon induced transmembrane protein 2
Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common ? chain (CSF2RB) protein stability.

Koochaki SHJ, Slabicki M, Lumpkin R, Zou C, Belizaire R, Fischer ES, Ebert BL

The IL-3, IL-5, and GM-CSF family of cytokines play an essential role in the growth, differentiation, and effector functions of multiple hematopoietic cell types. Receptors in this family are composed of cytokine-specific ? chains and a common ? chain (CSF2RB), responsible for the majority of downstream signaling. CSF2RB abundance and stability influence the magnitude of the cellular response to cytokine ... [more]

J Biol Chem Oct. 01, 2022; 298(10);102484 [Pubmed: 36108743]

Throughput

  • High Throughput

Curated By

  • BioGRID