BAIT
CHIC2
BTL
cysteine-rich hydrophobic domain 2
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PHGDH
3-PGDH, 3PGDH, 4930479N23, A10, PGAD, PGD, PGDH, SERA
3-phosphoglycerate dehydrogenase
GO Process (14)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- G1 to G0 transition [IMP]
- L-serine metabolic process [IMP]
- gamma-aminobutyric acid metabolic process [IMP]
- glial cell development [IMP]
- glutamine metabolic process [IMP]
- glycine metabolic process [IMP]
- neural tube development [IMP]
- neurogenesis [IMP]
- neuron projection development [IMP]
- oxidation-reduction process [ISO]
- regulation of gene expression [IMP]
- spinal cord development [IMP]
- taurine metabolic process [IMP]
- threonine metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common ? chain (CSF2RB) protein stability.
The IL-3, IL-5, and GM-CSF family of cytokines play an essential role in the growth, differentiation, and effector functions of multiple hematopoietic cell types. Receptors in this family are composed of cytokine-specific ? chains and a common ? chain (CSF2RB), responsible for the majority of downstream signaling. CSF2RB abundance and stability influence the magnitude of the cellular response to cytokine ... [more]
J Biol Chem Oct. 01, 2022; 298(10);102484 [Pubmed: 36108743]
Throughput
- High Throughput
Curated By
- BioGRID