BAIT
LEAP2
LEAP-2
liver expressed antimicrobial peptide 2
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
GHSR
growth hormone secretagogue receptor
GO Process (13)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- actin polymerization or depolymerization [IDA]
- adult feeding behavior [ISS]
- decidualization [IDA]
- growth hormone secretion [TAS]
- hormone-mediated signaling pathway [IDA]
- negative regulation of inflammatory response [IDA]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of interleukin-6 biosynthetic process [IDA]
- negative regulation of tumor necrosis factor biosynthetic process [IDA]
- positive regulation of appetite [ISS]
- positive regulation of multicellular organism growth [IMP]
- response to hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Identifying key residues and key interactions for the binding of LEAP2 to receptor GHSR1a.
Liver-expressed antimicrobial peptide 2 (LEAP2) was recently identified as a competitive antagonist for the G protein-coupled receptor GHSR1a, the cognate receptor for the gastric peptide ghrelin. LEAP2 plays important functions in energy metabolism by tuning the ghrelin-GHSR1a system. However, the molecular mechanism by which LEAP2 binds to GHSR1a is largely unknown. In the present study, we first conducted alanine-scanning mutagenesis ... [more]
Biochem J Sep. 18, 2020; 477(17);3199-3217 [Pubmed: 32803260]
Throughput
- Low Throughput
Curated By
- BioGRID