Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

KCTD9 inhibits the Wnt/?-catenin pathway by decreasing the level of ?-catenin in colorectal cancer.

Yao H, Ren D, Wang Y, Wu L, Wu Y, Wang W, Li Q, Liu L

Colorectal cancer (CRC) is the second leading cause of cancer mortality worldwide. However, the molecular mechanisms underlying CRC progression remain to be further defined to improve patient outcomes. In this study, we found that KCTD9, a member of the potassium channel tetramerization domain-containing (KCTD) gene family, was commonly downregulated in CRC tissues and that KCTD9 expression was negatively correlated with ... [more]

Cell Death Dis Sep. 02, 2022; 13(9);761 [Pubmed: 36055981]

Throughput

  • High Throughput

Curated By

  • BioGRID