BAIT
BRSK2
4833424K13Rik, SAD-A, SADA
BR serine/threonine kinase 2
GO Process (10)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [ISO]
- actin cytoskeleton reorganization [ISO]
- axonogenesis [IMP]
- establishment of cell polarity [IGI, IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO]
- neuron differentiation [IGI]
- neuron projection morphogenesis [IGI]
- peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ARHGEF7
Cool, PIX, Pak3bp, betaPix, betaPix-b, betaPix-c, cool-1, mKIAA0142, p85Cool1, p85SPR
Rho guanine nucleotide exchange factor (GEF7)
GO Process (11)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- astrocyte cell migration [ISO]
- focal adhesion assembly [ISO]
- hematopoietic progenitor cell differentiation [IGI]
- lamellipodium assembly [IMP]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rac GTPase activity [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of lamellipodium morphogenesis [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- small GTPase mediated signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.324623833 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID