BAIT
BTRC
Beta-Trcp1, E3RS-IkappaB, E3RSIkappaB, FWD1, Fbw1a, HOS, Slimb, b-TrCP, beta-TrCP
beta-transducin repeat containing protein
GO Process (19)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA]
- branching involved in mammary gland duct morphogenesis [IMP]
- cellular response to organic cyclic compound [IDA]
- mammary gland epithelial cell proliferation [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of circadian rhythm [IMP]
- positive regulation of proteolysis [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein catabolic process [IMP]
- protein dephosphorylation [IDA]
- protein destabilization [ISO]
- protein polyubiquitination [IDA]
- protein ubiquitination [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of cell cycle [IMP]
- regulation of circadian rhythm [ISO]
- regulation of proteasomal protein catabolic process [IDA]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ELFN2
6330514E13, AW048948, BC094219, Lrrc62, Ppp1r29
leucine rich repeat and fibronectin type III, extracellular 2
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.376824992 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID