BAIT
CDKL5
BC038161, Stk9, RP23-213O8.2
cyclin-dependent kinase-like 5
GO Process (6)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MINK1
B55, MINK, Map4k6, Ysk2, DN-183N8.7
misshapen-like kinase 1 (zebrafish)
GO Process (14)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- dendrite morphogenesis [ISO]
- intracellular signal transduction [IBA, IDA]
- negative thymic T cell selection [IMP]
- positive regulation of JNK cascade [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, IDA]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO]
- regulation of cell migration [ISO]
- regulation of cell-cell adhesion [ISO]
- regulation of cell-matrix adhesion [ISO]
- response to stress [IDA]
- signal transduction by phosphorylation [IBA]
- synaptic transmission [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.32538954 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID