BAIT
CNOT3
A930039N10Rik
CCR4-NOT transcription complex, subunit 3
GO Process (2)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MIF
GIF, Glif
macrophage migration inhibitory factor
GO Process (44)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IMP]
- brain renin-angiotensin system [ISO]
- carboxylic acid metabolic process [ISO]
- cell aging [IMP]
- cell proliferation [ISO]
- cell surface receptor signaling pathway [ISO]
- drinking behavior [ISO]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA, ISO]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of cell aging [ISO]
- negative regulation of cell cycle arrest [ISO]
- negative regulation of cellular protein metabolic process [IDA]
- negative regulation of gene expression [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- negative regulation of mature B cell apoptotic process [IDA]
- negative regulation of myeloid cell apoptotic process [IMP]
- positive chemotaxis [ISO]
- positive regulation of B cell proliferation [ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, ISO]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of acute inflammatory response [ISO]
- positive regulation of adaptive immune response [NAS]
- positive regulation of arachidonic acid secretion [IDA]
- positive regulation of axon regeneration [ISO]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- positive regulation of cytokine secretion [ISO]
- positive regulation of fibroblast proliferation [IDA, ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glycolytic process [ISO]
- positive regulation of immune response [ISO]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of myeloid leukocyte cytokine production involved in immune response [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of potassium ion transport [ISO]
- positive regulation of prostaglandin secretion involved in immune response [IMP]
- positive regulation of protein kinase A signaling [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of smooth muscle cell migration [ISO]
- prostaglandin biosynthetic process [ISO]
- protein homotrimerization [ISO]
- regulation of cell proliferation [IMP]
- spermatogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.205304312 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID