BAIT
CNTNAP2
5430425M22Rik, Caspr2, mKIAA0868
contactin associated protein-like 2
GO Process (10)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- adult behavior [ISO]
- cell adhesion [TAS]
- cellular protein localization [IMP]
- clustering of voltage-gated potassium channels [IMP]
- learning [ISO]
- neuron projection development [IGI]
- neuron recognition [TAS]
- protein localization to juxtaparanode region of axon [IMP]
- social behavior [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
AGAP2
AGAP-2, Centg1, PIKE, cnt-g1, mKIAA0167
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
GO Process (15)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- actin cytoskeleton organization [ISO]
- endosomal transport [ISO]
- mammary gland alveolus development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of mammary gland epithelial cell proliferation [IGI, IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
Gene Ontology Molecular Function
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.253280078 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID