BAIT
CNTNAP2
5430425M22Rik, Caspr2, mKIAA0868
contactin associated protein-like 2
GO Process (10)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- adult behavior [ISO]
- cell adhesion [TAS]
- cellular protein localization [IMP]
- clustering of voltage-gated potassium channels [IMP]
- learning [ISO]
- neuron projection development [IGI]
- neuron recognition [TAS]
- protein localization to juxtaparanode region of axon [IMP]
- social behavior [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GRIN2A
GluN2A, NMDAR2A, NR2A
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
GO Process (44)
GO Function (19)
GO Component (13)
Gene Ontology Biological Process
- action potential [ISO]
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IGI, IMP]
- cation transmembrane transport [ISO]
- cation transport [ISO]
- cellular response to amino acid stimulus [ISO]
- cellular response to zinc ion [ISO]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- directional locomotion [IGI]
- dopamine metabolic process [IMP]
- ion transmembrane transport [IGI, ISO]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- learning [IMP]
- learning or memory [IMP]
- locomotion [IMP]
- locomotory behavior [TAS]
- memory [IMP, ISO]
- negative regulation of protein catabolic process [IGI]
- neurogenesis [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of cell death [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- protein localization [IGI, IMP]
- protein tetramerization [ISO]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP, ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [IMP]
- regulation of postsynaptic membrane potential [IMP]
- regulation of sensory perception of pain [IMP]
- regulation of synaptic plasticity [IMP]
- regulation of synaptic transmission [IMP]
- response to amphetamine [IMP]
- response to drug [IMP]
- response to ethanol [IMP, ISO]
- response to wounding [IGI, IMP]
- rhythmic process [ISO]
- sensory perception of pain [IMP]
- serotonin metabolic process [IMP]
- sleep [IMP]
- startle response [IGI, IMP]
- synaptic transmission [IMP, ISO]
- synaptic transmission, glutamatergic [IBA]
- visual learning [IMP]
Gene Ontology Molecular Function- ATPase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- calcium channel activity [IGI, IMP]
- cation channel activity [IMP, ISO]
- cell adhesion molecule binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- voltage-gated cation channel activity [ISO]
- zinc ion binding [ISO]
- ATPase binding [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IGI, IMP, ISO]
- calcium channel activity [IGI, IMP]
- cation channel activity [IMP, ISO]
- cell adhesion molecule binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA, ISO]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- receptor binding [ISO]
- scaffold protein binding [ISO]
- voltage-gated cation channel activity [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IPI, ISO]
- cell surface [IDA]
- dendritic spine [ISA]
- endoplasmic reticulum [IDA]
- membrane [IDA]
- neuron projection [IDA, ISO]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA, ISO]
- synapse [IDA]
- synaptic vesicle [IDA]
- terminal bouton [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.289334414 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID