BAIT
CNTNAP2
5430425M22Rik, Caspr2, mKIAA0868
contactin associated protein-like 2
GO Process (10)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- adult behavior [ISO]
- cell adhesion [TAS]
- cellular protein localization [IMP]
- clustering of voltage-gated potassium channels [IMP]
- learning [ISO]
- neuron projection development [IGI]
- neuron recognition [TAS]
- protein localization to juxtaparanode region of axon [IMP]
- social behavior [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRMT1
6720434D09Rik, AW214366, Hrmt1l2, Mrmt1
protein arginine N-methyltransferase 1
GO Process (11)
GO Function (13)
GO Component (3)
Gene Ontology Biological Process
- histone H4-R3 methylation [IBA, ISO]
- histone methylation [IDA, ISO]
- in utero embryonic development [IMP]
- negative regulation of megakaryocyte differentiation [ISO]
- neuron projection development [ISO]
- peptidyl-arginine N-methylation [IDA]
- peptidyl-arginine methylation [ISO]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA, ISO]
- peptidyl-arginine omega-N-methylation [ISO]
- protein methylation [IMP, ISO]
- regulation of transcription, DNA-templated [IBA]
Gene Ontology Molecular Function- N-methyltransferase activity [ISO]
- [cytochrome c]-arginine N-methyltransferase activity [ISO]
- histone methyltransferase activity [IDA, ISO]
- histone methyltransferase activity (H4-R3 specific) [IBA, ISO]
- histone-arginine N-methyltransferase activity [ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein methyltransferase activity [IMP, ISO]
- protein-arginine N-methyltransferase activity [IDA, ISO]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA, ISO]
- protein-arginine omega-N monomethyltransferase activity [ISO]
- snoRNP binding [ISO]
- N-methyltransferase activity [ISO]
- [cytochrome c]-arginine N-methyltransferase activity [ISO]
- histone methyltransferase activity [IDA, ISO]
- histone methyltransferase activity (H4-R3 specific) [IBA, ISO]
- histone-arginine N-methyltransferase activity [ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein methyltransferase activity [IMP, ISO]
- protein-arginine N-methyltransferase activity [IDA, ISO]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA, ISO]
- protein-arginine omega-N monomethyltransferase activity [ISO]
- snoRNP binding [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.253391563 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID