BAIT
CNTNAP2
5430425M22Rik, Caspr2, mKIAA0868
contactin associated protein-like 2
GO Process (10)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- adult behavior [ISO]
- cell adhesion [TAS]
- cellular protein localization [IMP]
- clustering of voltage-gated potassium channels [IMP]
- learning [ISO]
- neuron projection development [IGI]
- neuron recognition [TAS]
- protein localization to juxtaparanode region of axon [IMP]
- social behavior [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PTPN2
AI325124, Ptpt, TC-PTP
protein tyrosine phosphatase, non-receptor type 2
GO Process (31)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- T cell differentiation [IMP]
- erythrocyte differentiation [IMP]
- glucose homeostasis [IMP]
- insulin receptor signaling pathway [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of chemotaxis [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [IMP]
- negative regulation of interleukin-2-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-4-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-6-mediated signaling pathway [IMP, ISO]
- negative regulation of lipid storage [IMP]
- negative regulation of macrophage colony-stimulating factor signaling pathway [IMP]
- negative regulation of macrophage differentiation [IMP]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [IMP]
- negative regulation of positive thymic T cell selection [IMP]
- negative regulation of prolactin signaling pathway [IMP]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IMP]
- negative regulation of type I interferon-mediated signaling pathway [IMP, ISO]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- negative regulation of tyrosine phosphorylation of Stat6 protein [IMP, ISO]
- peptidyl-tyrosine dephosphorylation [IMP, ISO]
- positive regulation of gluconeogenesis [IMP]
- protein dephosphorylation [IMP]
- regulation of hepatocyte growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.219363063 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID