BAIT
CORO1A
Clabp, Lmb3, TACO, p57
coronin, actin binding protein 1A
GO Process (26)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- T cell homeostasis [IMP]
- actin cytoskeleton organization [ISO]
- actin filament organization [IMP]
- calcium ion transport [IMP]
- cell migration [IMP]
- cell-substrate adhesion [ISO]
- cellular response to interleukin-4 [IDA]
- early endosome to recycling endosome transport [IMP]
- homeostasis of number of cells within a tissue [IMP]
- leukocyte chemotaxis [IMP]
- negative regulation of actin nucleation [IBA, ISO]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of vesicle fusion [IMP]
- nerve growth factor signaling pathway [IGI]
- phagocytosis [ISO]
- phagolysosome assembly [IBA, ISO]
- positive chemotaxis [IBA, ISO]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of cell migration [IMP]
- regulation of actin filament polymerization [IMP]
- regulation of actin polymerization or depolymerization [IMP]
- regulation of cell shape [IMP]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- response to cytokine [IMP]
- uropod organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- actin filament [ISO]
- axon [IDA]
- cell [IMP]
- cell leading edge [IDA]
- cell-cell junction [IDA]
- cortical actin cytoskeleton [IBA, ISO]
- cytoplasm [ISO]
- early endosome [IDA]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA]
- intracellular [IMP]
- lamellipodium [IBA, ISO]
- membrane [ISO]
- phagocytic cup [IBA, ISO]
- phagocytic vesicle [IBA, ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
Mus musculus
PREY
CDC42
AI747189, AU018915, RP23-246F18.2
cell division cycle 42
GO Process (50)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- GTP catabolic process [ISA]
- Golgi organization [ISO]
- Rho protein signal transduction [TAS]
- actin filament branching [ISO]
- actin filament bundle assembly [IMP]
- actin filament organization [ISO]
- adherens junction organization [IMP]
- canonical Wnt signaling pathway [IMP]
- cardiac conduction system development [IGI]
- cellular protein localization [IMP]
- dendritic cell migration [IGI]
- endosomal transport [TAS]
- epidermis morphogenesis [IMP]
- epithelial cell-cell adhesion [IMP]
- epithelial-mesenchymal cell signaling [IMP]
- establishment of Golgi localization [ISO]
- establishment or maintenance of apical/basal cell polarity [IMP]
- establishment or maintenance of cell polarity [TAS]
- filopodium assembly [IDA]
- hair follicle morphogenesis [IMP]
- hair follicle placode formation [IMP]
- heart contraction [IGI]
- keratinization [IMP]
- keratinocyte development [IMP]
- multicellular organism growth [IMP]
- negative regulation of gene expression [IMP]
- neuron fate determination [IMP]
- nuclear migration [IMP]
- nucleus localization [IMP]
- organelle transport along microtubule [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of hair follicle cell proliferation [IMP]
- positive regulation of intracellular protein transport [ISO]
- positive regulation of metalloenzyme activity [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of synapse structural plasticity [ISO]
- regulation of mitosis [IMP]
- regulation of protein catabolic process [IMP]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein kinase activity [IMP]
- regulation of protein metabolic process [IMP]
- regulation of protein stability [IMP]
- single organismal cell-cell adhesion [IMP, TAS]
- sprouting angiogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.20068171 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID