CORO1A
Gene Ontology Biological Process
- T cell homeostasis [IMP]
- actin cytoskeleton organization [ISO]
- actin filament organization [IMP]
- calcium ion transport [IMP]
- cell migration [IMP]
- cell-substrate adhesion [ISO]
- cellular response to interleukin-4 [IDA]
- early endosome to recycling endosome transport [IMP]
- homeostasis of number of cells within a tissue [IMP]
- leukocyte chemotaxis [IMP]
- negative regulation of actin nucleation [IBA, ISO]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of vesicle fusion [IMP]
- nerve growth factor signaling pathway [IGI]
- phagocytosis [ISO]
- phagolysosome assembly [IBA, ISO]
- positive chemotaxis [IBA, ISO]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of cell migration [IMP]
- regulation of actin filament polymerization [IMP]
- regulation of actin polymerization or depolymerization [IMP]
- regulation of cell shape [IMP]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- response to cytokine [IMP]
- uropod organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- actin filament [ISO]
- axon [IDA]
- cell [IMP]
- cell leading edge [IDA]
- cell-cell junction [IDA]
- cortical actin cytoskeleton [IBA, ISO]
- cytoplasm [ISO]
- early endosome [IDA]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA]
- intracellular [IMP]
- lamellipodium [IBA, ISO]
- membrane [ISO]
- phagocytic cup [IBA, ISO]
- phagocytic vesicle [IBA, ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
PPP1R9B
Gene Ontology Biological Process
- actin cytoskeleton organization [TAS]
- actin filament organization [IPI]
- calcium-mediated signaling [IMP]
- cell migration [ISO]
- cellular response to morphine [IMP]
- dendrite development [IMP]
- filopodium assembly [ISO]
- negative regulation of cell growth [ISO]
- regulation of opioid receptor signaling pathway [IMP]
- regulation of protein phosphorylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Quantitative Score
- 0.228931068 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPP1R9B CORO1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID