BAIT
MPS2
MMC1, L000004546, L000004250, YGL075C
Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
SCP160
L000001817, YJL080C
Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
GO Process (7)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- chemotropism [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IGI, IMP]
- chromosome segregation [IMP]
- intracellular mRNA localization [IPI]
- meiotic telomere clustering [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The SESA network links duplication of the yeast centrosome with the protein translation machinery.
The yeast spindle pole body (SPB), the functional equivalent of mammalian centrosome, duplicates in G1/S phase of the cell cycle and then becomes inserted into the nuclear envelope. Here we describe a link between SPB duplication and targeted translation control. When insertion of the newly formed SPB into the nuclear envelope fails, the SESA network comprising the GYF domain protein ... [more]
Genes Dev. Jul. 01, 2009; 23(13);1559-70 [Pubmed: 19571182]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- deletion of SCP160 blocks the rescue usually seen by overexpressing SMY2 in an MPS2 mutant background
Curated By
- BioGRID