BAIT
ETFB
0610009I16Rik, 2810441H06Rik
electron transferring flavoprotein, beta polypeptide
GO Process (0)
GO Function (1)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LONP1
1200017E13Rik, LON, Prss15
lon peptidase 1, mitochondrial
GO Process (10)
GO Function (13)
GO Component (5)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- cellular protein complex assembly [ISO]
- cellular response to oxidative stress [ISO]
- chaperone-mediated protein complex assembly [IBA]
- misfolded or incompletely synthesized protein catabolic process [IBA]
- mitochondrion organization [IBA, ISO]
- oxidation-dependent protein catabolic process [ISO]
- protein homooligomerization [ISO]
- proteolysis [IDA, ISO]
- proteolysis involved in cellular protein catabolic process [ISO]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATP-dependent peptidase activity [IDA, ISO]
- ATPase activity [IDA]
- DNA polymerase binding [ISO]
- G-quadruplex DNA binding [ISO]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA, ISO]
- mitochondrial light strand promoter sense binding [IDA]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATP-dependent peptidase activity [IDA, ISO]
- ATPase activity [IDA]
- DNA polymerase binding [ISO]
- G-quadruplex DNA binding [ISO]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA, ISO]
- mitochondrial light strand promoter sense binding [IDA]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.121298326 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID