BAIT
GPHN
5730552E08Rik, AI662856, BC027112, C230040D23, GPH, GPHRYN, geph
gephyrin
GO Process (6)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- Mo-molybdopterin cofactor biosynthetic process [IMP, ISO]
- establishment of protein localization [ISO]
- establishment of synaptic specificity at neuromuscular junction [IMP]
- glycine receptor clustering [IMP]
- molybdenum incorporation into molybdenum-molybdopterin complex [IBA]
- protein homooligomerization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
USP9X
5730589N07Rik, AA407302, AA407699, AL022658, AL022749, Dffrx, FAF-X, Fafl, RP23-216M21.1
ubiquitin specific peptidase 9, X chromosome
GO Process (13)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- axon extension [IMP, ISO]
- cellular response to transforming growth factor beta stimulus [IMP]
- cerebellar cortex structural organization [IMP]
- hippocampus development [IMP]
- in utero embryonic development [IGI]
- neuron migration [IMP, ISO]
- neuron projection extension [IGI]
- post-embryonic development [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IBA, ISO]
- regulation of proteasomal protein catabolic process [IBA]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.253959333 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID