BAIT
GRIA2
GluA2, GluR-B, Glur-2, Glur2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
GO Process (10)
GO Function (9)
GO Component (22)
Gene Ontology Biological Process
- establishment of protein localization [ISO]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- positive regulation of synaptic transmission [ISO]
- protein tetramerization [ISO]
- receptor internalization [ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic transmission, glutamatergic [ISO]
- synaptic transmission [IDA, ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- cell surface [ISO]
- dendrite [IBA, ISO]
- dendrite cytoplasm [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum [IDA]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [ISO]
- perikaryon [ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, IDA]
- presynaptic membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [ISO]
- terminal bouton [ISO]
Mus musculus
PREY
CACNA1A
APCA, BI, Caca1a, Cacnl1a4, Cav2.1, Ccha1a, EA2, FHM, HPCA, MHP, MHP1, SCA6, alpha1A, la, nmf352, rkr, tg
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
GO Process (50)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- adult walking behavior [IGI, IMP]
- behavioral response to pain [IMP]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IGI]
- calcium ion transport [IMP, ISO]
- calcium ion-dependent exocytosis [IMP]
- calcium ion-dependent exocytosis of neurotransmitter [IMP]
- cell death [ISO]
- cell growth [IMP]
- cellular chloride ion homeostasis [IMP]
- central nervous system neuron differentiation [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebellar molecular layer development [IMP]
- cerebellum maturation [IMP]
- dendrite morphogenesis [IMP]
- gamma-aminobutyric acid secretion [IMP]
- gamma-aminobutyric acid signaling pathway [IMP]
- glucose metabolic process [IMP]
- hormone metabolic process [IMP]
- membrane depolarization [IMP]
- membrane depolarization during action potential [IBA]
- musculoskeletal movement, spinal reflex action [IMP]
- negative regulation of hormone biosynthetic process [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neurological system process [IMP]
- neuromuscular process [IGI, IMP]
- neuromuscular process controlling balance [IMP]
- neuromuscular synaptic transmission [IMP]
- neuron-neuron synaptic transmission [IMP]
- neurotransmitter metabolic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- receptor clustering [IMP]
- regulation of acetylcholine secretion, neurotransmission [IMP]
- regulation of axonogenesis [IMP]
- regulation of calcium ion-dependent exocytosis [IDA]
- regulation of ion transmembrane transport [IGI]
- regulation of membrane potential [IMP]
- response to pain [IMP]
- rhythmic synaptic transmission [IMP]
- sensory perception of pain [ISO]
- spinal cord motor neuron differentiation [IMP]
- sulfur amino acid metabolic process [IMP]
- synapse assembly [IMP]
- synaptic transmission [IMP, ISO]
- synaptic transmission, GABAergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- thyroid hormone metabolic process [IMP]
- transmission of nerve impulse [IMP]
- vestibular nucleus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.227535494 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID