BAIT
GRIA2
GluA2, GluR-B, Glur-2, Glur2
glutamate receptor, ionotropic, AMPA2 (alpha 2)
GO Process (10)
GO Function (9)
GO Component (22)
Gene Ontology Biological Process
- establishment of protein localization [ISO]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISO]
- positive regulation of synaptic transmission [ISO]
- protein tetramerization [ISO]
- receptor internalization [ISO]
- regulation of receptor recycling [ISO]
- regulation of synaptic transmission, glutamatergic [ISO]
- synaptic transmission [IDA, ISO]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
- PDZ domain binding [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IBA, ISO]
- extracellular-glutamate-gated ion channel activity [IDA]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IDA, ISO]
- kainate selective glutamate receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor activity [ISO]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [ISO]
- cell surface [ISO]
- dendrite [IBA, ISO]
- dendrite cytoplasm [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- endoplasmic reticulum [IDA]
- growth cone [ISO]
- integral component of plasma membrane [ISO]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [ISO]
- perikaryon [ISO]
- postsynaptic density [ISO]
- postsynaptic membrane [IBA, IDA]
- presynaptic membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [ISO]
- terminal bouton [ISO]
Mus musculus
PREY
ERBB4
Her4, c-erbB-4, AC167658.1
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
GO Process (33)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- cardiac muscle tissue regeneration [IMP]
- cell fate commitment [IDA]
- cell migration [ISO]
- central nervous system morphogenesis [IMP]
- embryonic pattern specification [IMP]
- heart development [IMP]
- lactation [IMP, ISO]
- mammary gland alveolus development [IMP]
- mammary gland epithelial cell differentiation [IMP]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- nervous system development [IMP]
- neural crest cell migration [IMP]
- olfactory bulb interneuron differentiation [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of STAT protein import into nucleus [IMP, ISO]
- positive regulation of cardiac muscle cell proliferation [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP, ISO]
- protein autophosphorylation [ISO]
- regulation of cell migration [IMP]
- signal transduction [ISO]
- surfactant homeostasis [ISO]
- synapse maturation [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID2) to identify protein-protein interaction (PPI) networks for 41 ASD risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missense variants. The PPI network map reveals convergent pathways, including ... [more]
Cell Rep Nov. 22, 2022; 41(8);111678 [Pubmed: 36417873]
Quantitative Score
- 0.282134667 [Relative Biotinylation Score]
Throughput
- High Throughput
Additional Notes
- BioID experiment
- The scores are relative biotinylation enrichment scores (calculated as a percentage of the abundance fold change of the highest biotinylated prey protein)
- The statistical cut-offs for the prey proteins are based on adjusted t-test p-value and significance B scores of less than 0.05, by comparing average abundances of prey proteins between the Bait-BioID samples and the luciferase-BioID control
Curated By
- BioGRID